Factors | Cohort (n) | Cases (n) | Crude HR (95% CI), p | Multi-adjusted HR (95% CI)*, p |
Age at menarche, y | | | | |
≤11 | 14,263 | 50 | Reference | Reference |
12–13 | 37,820 | 119 | 0.88 (0.64-1.23), p=0.467 | 0.86 (0.62-1.20), p=0.386 |
14–15 | 15,101 | 54 | 1.00 (0.68-1.47), p=0.998 | 0.95 (0.64-1.40), p=0.787 |
≥16 | 3,206 | 13 | 1.15 (0.62-2.11), p=0.656 | 1.09 (0.59-2.00), p=0.794 |
Parity | | | | |
Nulliparous | 6,452 | 20 | Reference | Reference |
Parous | 64,021 | 217 | 1.07 (0.68-1.69), p=0.768 | 1.03 (0.65-1.63), p=0.903 |
No. of live births | | | | |
0 | 6,452 | 20 | Reference | Reference |
1–2 | 21,892 | 72 | 1.05 (0.64-1.73), p=0.833 | 1.05 (0.64-1.72), p=0.849 |
3–4 | 29,254 | 102 | 1.09 (0.68-1.77), p=0.714 | 1.04 (0.64-1.68), p=0.873 |
≥5 | 12,875 | 43 | 1.05 (0.62-1.78), p=0.863 | 0.97 (0.57-1.65), p=0.904 |
Age at first live birth, y | | | | |
<20 | 12,059 | 36 | 0.81 (0.56-1.17), p=0.256 | 0.77 (0.53-1.13), p=0.177 |
20–24 | 32,763 | 126 | Reference | Reference |
25–29 | 14,113 | 40 | 0.73 (0.51-1.04), p=0.083 | 0.76 (0.53-1.08), p=0.127 |
≥30 | 4,868 | 13 | 0.69 (0.39-1.22), p=0.205 | 0.73 (0.41-1.30), p=0.284 |
Ever had stillbirth | | | | |
0 | 66,986 | 230 | Reference | Reference |
1 | 2,478 | 5 | 0.60 (0.25-1.45), p=0.256 | 0.56 (0.23-1.36), p=0.203 |
≥2 | 598 | 2 | 1.03 (0.26-4.15), p=0.965 | 1.02 (0.25-4.09), p=0.983 |
No. of miscarriages | | | | |
0 | 46,249 | 153 | Reference | Reference |
1 | 15,520 | 56 | 1.09 (0.80-1.48), p=0.586 | 1.07 (0.78-1.45), p=0.682 |
≥2 | 8,575 | 28 | 0.99 (0.66-1.48), p=0.965 | 0.94 (0.63-1.40), p=0.751 |
Age at menopause, y | | | | |
<45 | 19,607 | 76 | 1.32 (0.96-1.81), p=0.088 | 1.25 (0.91-1.71), p=0.176 |
45–49 | 16,675 | 57 | 1.14 (0.81-1.60), p=0.457 | 1.08 (0.77-1.52), p=0.658 |
50–54 | 25,748 | 78 | Reference | Reference |
≥55 | 7,942 | 25 | 1.04 (0.66-1.62), p=0.88 | 1.14 (0.73-1.80), p=0.557 |
Type of Menopause | | | | |
Natural Menopause | 43,571 | 151 | Reference | Reference |
Surgery | 23,314 | 80 | 1.02 (0.77-1.33), p=0.907 | 1.06 (0.81-1.39), p=0.666 |
Drug Therapy | 2,325 | 4 | 0.50 (0.19-1.35). p=0.171 | 0.59 (0.22-1.60). p=0.301 |
History of hysterectomy | | | | |
No | 45,410 | 153 | Reference | Reference |
Yes | 25,000 | 84 | 1.02 (0.78-1.34), p=0.866 | 1.05 (0.80-1.37), p=0.738 |
Age at hysterectomy, y | | | | |
<40 | 8,780 | 31 | Reference | Reference |
40–44 | 6,121 | 23 | 1.06 (0.62-1.81), p=0.837 | 1.02 (0.59-1.76), p=0.939 |
45–49 | 5,164 | 22 | 1.19 (0.69-2.05), p=0.537 | 1.20 (0.69-2.08), p=0.515 |
≥50 | 4,843 | 8 | 0.46 (0.21-1.01), p=0.052 | 0.46 (0.21-1.00), p=0.051 |
Oophorectomy status | | | | |
No | 55,379 | 190 | Reference | Reference |
Yes | 13,936 | 42 | 0.92 (0.66-1.28), p=0.608 | 0.92 (0.66-1.29), p=0.631 |
OC use | | | | |
Never | 32,178 | 112 | Reference | Reference |
Ever | 38,279 | 125 | 0.95 (0.74-1.23), p=0.711 | 1.07 (0.81-1.40), p=0.639 |
Duration of OC use, y | | | | |
Never | 32,166 | 112 | Reference | Reference |
1–3 | 17,862 | 62 | 1.01 (0.74-1.38), p=0.939 | 1.13 (0.82-1.56), p=0.471 |
4–5 | 5,205 | 13 | 0.73 (0.41-1.30), p=0.286 | 0.87 (0.48-1.55), p=0.628 |
6–9 | 6,300 | 22 | 1.02 (0.64-1.61), p=0.940 | 1.15 (0.72-1.84), p=0.554 |
≥10 | 8,835 | 27 | 0.89 (0.58-1.35), p=0.586 | 0.96 (0.62-1.48), p=0.850 |
HRT use | | | | |
Never | 22,921 | 69 | Reference | Reference |
Ever | 47,062 | 168 | 1.18 (0.89-1.56), p=0.243 | 1.32 (0.99-1.76), p=0.057 |
Duration of HRT use, y | | | | |
Never | 22,921 | 69 | Reference | Reference |
≤5 | 21,299 | 74 | 1.14 (0.82-1.59), p=0.425 | 1.30 (0.93-1.81), p=0.125 |
6–9 | 8,668 | 20 | 0.76 (0.46-1.24), p=0.271 | 0.92 (0.55-1.53), p=0.740 |
≥10 | 17,095 | 74 | 1.45 (1.05-2.02), p=0.026 | 1.50 (1.08-2.09), p=0.017 |