After stratifying the two age groups, we found that ISH was significantly associated with higher LVMI compared with the NM group in both younger and older patients (+14.4 g/m2 and +8.8 g/m2, respectively, both P<0.05). SDH was also significantly associated with higher LVMI in both younger and older patients (+14.4 g/m2 and +5.4 g/m2, respectively, both P<0.05). There was no relationship between IDH and LVMI in either age group (Figure 1).
Figure 1. Relationship between left ventricular mass index (LVMI), the Log (estimated glomerular filtration rate) (eGFR), and the Log (albumin creatinine ratio) (ACR) and blood pressure types in different age groups. In patients under 60 years old, adjusted variables for LVMI include gender, age, BMI, current smoker, diabetes mellitus, CVD history, antihypertensive drugs, hemoglobin, uric acid, HDL-C, LDL-C, serum albumin, serum phosphate, iPTH, eGFR, ISH, IDH, SDH; adjusted variables for Log (eGFR) include gender, age, BMI, current smoker, alcohol intake, diabetes mellitus, hyperlipidemia, CVD history, antihypertensive drugs, hemoglobin, uric acid, total cholesterol, HDL-C, LDL-C, serum phosphate, iPTH, ISH, IDH, SDH; adjusted variables for Log (ACR) include gender, age, alcohol intake, diabetes mellitus, antihypertensive drugs, hemoglobin, uric acid, triglyceride, total cholesterol, HDL-C, LDL-C, serum albumin, serum phosphate, iPTH, eGFR, ISH, IDH, SDH. In patients at and above 60 years old, adjusted variables for LVMI include gender, current smoker, hyperlipidemia, CVD history, antihypertensive drugs, hemoglobin, uric acid, HDL-C, serum phosphate, iPTH, eGFR, ISH, IDH, SDH; adjusted variables for Log (eGFR) include gender, age, BMI, hyperlipidemia, antihypertensive drugs, hemoglobin, uric acid, triglyceride, HDL-C, LDL-C, serum phosphate, iPTH, ISH, IDH, SDH; adjusted variables for Log (ACR) include gender, diabetes mellitus, antihypertensive drugs, hemoglobin, HDL-C, LDL-C, serum albumin, serum calcium, serum phosphate, iPTH, eGFR, ISH, IDH, SDH. BMI, body mass index; CVD, cardiovascular disease; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; iPTH, intact parathyroid hormone; NM, normotension; ISH, isolated systolic hypertension; IDH, isolated diastolic hypertension; SDH, systolic and diastolic hypertension; LVMI, left ventricular mass index; eGFR, estimated glomerular filtration rate; ACR, albumin creatinine ratio. * P <0.05.
Compared with NM, ISH was significantly associated with lower eGFR in both younger and older patients (−0.2 log units and −0.2 log units, respectively, both P<0.05). SDH was also significantly associated with lower eGFR in both younger and older patients (−0.4 log units and −0.3 log units, respectively, both P<0.05). IDH was only negatively associated with eGFR among younger patients (−0.2 log units, P<0.05) (Figure 1).
Compared with NM, ISH was significantly associated with higher ACR in both younger and older patients (+0.5 log units and +1.0 log units, respectively, both P<0.05). SDH was also significantly associated with higher ACR in both younger and older patients (+0.5 log units and +0.6 log units, respectively, both P<0.05). IDH was only positively correlated with ACR among young patients (+0.4 log units, P<0.05) (Figure 1).