Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

Yong Pan; Gerald S. Shadel

doi:doi:10.18632/aging.100016

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Research Paper Volume 1, Issue 1 pp 131—145

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

Figure 6. Sch9p is the downstream mediator of TOR-dependent decreases in ROS level and chronological life span extension. Analysis of cellular ROS and chronological life span in the same strains shown in Figure 5. (A) FACS analysis of day 2 stationary phase cells stained for cellular superoxide using dihyroethidium (DHE) is shown. The mean fluorescence intensity is plotted +/- one standard deviation (** represents a p-value <0.01 according to a student's t-test). (B) Chronological life span plotted as described in Figure 4B.