Research Paper Volume 1, Issue 2 pp 191—211

A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila

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Figure 5. Mortality rate analysis of female larvae with and without Baculovirus p35 transgene expression. Open circles represent the no-drug control ("-"). Solid squares represent larvae cultured with drug ("L"). (A, B) Baculovirus p35 transgene on X chromosome. (C, D) Baculovirusp35 transgeneon second chromosome. (E, F) Baculovirus p35 transgene on third chromosome. (A, C, E) Plots of natural-log mortality rate vs. age in days. (B, D, F) The data were fitted to the Gompertz-Makeham model, which best described the mortality rate. The age-independent mortality was removed and the survival curves were re-drawn using only the Gompertz components. Mortality rate analysis showed that age-independent mortality was significantly higher for female larvae on drug versus control for all three Baculovirus p35 lines (Table 4).