Figure 3.Examples of EEE. (a) Depicts chromosomes of a newborn male
with enhanced signal intensity at one p arm of chromosome 15 and at both
chromatids of chromosome 16, (b). This is also the case at a single
chromatid of 15q and on both chromatids of chromosome 7q in a 50-year-old
male and, (c) at a single chromatid of chromosome 9p and at both
arms of chromosome 10q in a male centenarian. (d) Schematic view of
endoreduplication (ER), the result being a group of four homologous
chromatids which emerged from one single chromatid. Note that the
juxtapositions of the sister and descendant chromatids may be variable,
since their three-dimensional packing is broken up by chromosome spreading.
(e) Single chromosomes of a sporadic ER observed in a 40-year-old
female with features of EEE. Since telomeric EEEs at 2p, 5q, 6q, and 10p
are doublets and not quadruplets, EEE at these positions must have occurred
one cell cycle prior to the ER event. In addition, there is a single
telomeric EEE at 19q, which must have occurred during the S-phase directly
preceding this ER.
