Research Paper Volume 2, Issue 7 pp 393—414
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes
Figure 5. In chronologically aging WT yeast, the life-extending efficacy of LCA under CR exceeds that under non-CR conditions. (A - F) Effect of various concentrations of LCA on survival (A - D) and on the fold increase in the mean (E) or maximum (F) life span of chronologically aging WT strain cultured in medium initially containing 0.2%, 0.5%, 1% or 2% glucose. Data are presented as means ± SEM (n = 3-28). (G - I) Effect of 50 μM LCA on the mean or maximum CLS of WT yeast cultured in medium initially containing 0.2%, 0.5%, 1% or 2% glucose. Data are presented as means ± SEM (n = 12-28; ***p < 0.001).