Research Paper Volume 2, Issue 10 pp 650—658

Figure 4. Impaired telomerase activity reduces islet number and size by impairing the replicative potential of pancreatic beta-cells. (A, B) shows the number of BrdU-positive cells per insulin-positive area (A) and after additional normalization to body mass (B). (C, D) depict the number of BrdU-positive cells per standardized individual insulin-positive area (C) and after additional normalization to body mass (D). Black bars reflect control genotypes (n=9) and grey bars indicate Terc-/- G4 animals (n=10).