Research Perspective Volume 3, Issue 2 pp 158—161

SIRT-ain relief from age-inducing stress


Figure 1. Calorie restriction activates SIRT3 to reduce oxidative stress and combat aging. Calorie restriction promotes the activity of SIRT3, which deacetylates SOD2 and IDH2, increasing the activity of these enzymes and resulting in reduced oxidative stress. Lowered oxidative stress leads to a reduced rate of aging.