Research Perspective Volume 3, Issue 2 pp 158—161

Figure 2. SIRT3 protects genomic stability to combat aging and cancer. DNA damage plays a causal role in aging and cancer. The damage activates “gate-keeping” tumor suppressors like p53, which protect against cancer, but can promote aging. “Care-taking” tumor suppressors like SIRT3 protect against DNA damage, which may result in protection against both aging and cancer.