Research Paper Volume 3, Issue 5 pp 533—542

Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans


Figure 3. Oral glucose tolerance test results for subjects with abnormal glucose tolerance at baseline. The reduction in the glucose area under the curve (AUC) in the DHEA group (panel C) was significantly greater than that for the placebo group (panel A, p=0.03). Changes in insulin area under the curve did not differ between groups (panels B and D, p=0.52). Improvements in the glucose area under the curve were maintained in a subset of DHEA group participants who underwent a second year of DHEA supplementation (panel E). *p<0.05 for baseline versus DHEA.