Review Volume 3, Issue 9 pp 829—835

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair


Figure 2. SIRT6 regulates genomic stability. SIRT6 promotes genome stability by regulating DNA single-strand and double strand break repair pathways and by facilitating telomere maintenance. The deacetylase and the mono-ADP ribosyltransferase activities of SIRT6 both contribute to this function.