Research Perspective Volume 3, Issue 11 pp 1063—1077

Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer


Figure 1. Chronic exposure to metformin suppresses the proliferative activity of human [A431] cancer cells (A) to enter a form of permanent cell-cycle arrest accompanied by the induction of “self-digesting” autophagy (B).