Research Paper Volume 3, Issue 12 pp 1178—1191

Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective


Figure 1. Fraction of CS, longevity and ARD proteins forming a continuous PPI network. Values obtained from simulations with sets of randomly selected proteins are presented as dots. For all the sets of interest, the fraction of interconnected proteins was significantly higher than expected by chance (p < E-25). Insert: average connectivity (number of first-order protein partners) of the sets analyzed in this study. For more details, see Materials and Methods.