Research Perspective Volume 3, Issue 12 pp 1163—1168

Sir2 plays a key role in cell fate determination upon SAPK activation


Figure 2. Scheme of Hog1-induced Msn2/Msn4 dependent gene expression upon SCFcdc4 regulation. Activation of Hog1 SAPK induces the activation of Msn2/Msn4-dependent genes, such as PNC1. The E3 SCFcdc4 ubiquitin ligase ubiquitylates the transcription factors to promote their degradation. Partial inactivation of SCFcdc4 decreases Msn2/4 degradation, which results in an increased accumulation of the TFs at the promoters and to an increase in Msn2/Msn4 dependent gene expression.