Research Paper Volume 4, Issue 12 pp 923—931

P73 and age-related diseases: is there any link with Parkinson Disease?


Figure 4. p73 counteracts depletion of Th by 6-OHDA. N2a cells were transiently transfected with human TAp73 or shRNA against p73. After 48 hours, cells were treated with 10μM (final concentration) of 6-OHDA and collected at the indicated time points. Protein extracts were subjected to western blot analysis and quantified with densitometry. 6-OHDA = 6-hydroxydopamine, Th = tyrosine hydroxylase, GAPDH = Glyceraldehyde 3-phosphate dehydrogenase. Experiment has been reproduced at least 3 times.