Volume 4, Issue 12

December 2012
pp 854—977
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Table of Contents

Editorials

Geropotency: Increased malignant potential of aging neural progenitors

Andrei M. Mikheev, Elizabeth A. Stoll, Rohan Ramakrishna, Svetlana A. Mikheeva, Philip J. Horner, Robert C. Rostomily,

https://doi.org/10.18632/aging.100514 pp 854—855

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Heat shock response and ionstasis: axis against neurodegeneration

Nikos Kourtis, Vassiliki Nikoletopoulou, Nektarios Tavernarakis,

https://doi.org/10.18632/aging.100517 pp 856—858

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Mitochondria, obesity and aging

Cecile Vernochet, C. Ronald Kahn,

https://doi.org/10.18632/aging.100518 pp 859—860

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Reviews

Answering the ultimate question “What is the Proximal Cause of Aging?”

Mikhail V. Blagosklonny,

https://doi.org/10.18632/aging.100525 pp 861—877

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Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin?

Francesco Romeo, Francesco Costanzo, Massimiliano Agostini,

https://doi.org/10.18632/aging.100513 pp 878—886

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Recent discoveries in the cycling, growing and aging of the p53 field

James A. McCubrey, Zoya N. Demidenko,

https://doi.org/10.18632/aging.100529 pp 887—893

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Research Perspective

One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metformin

Javier A. Menendez, Jorge Joven,

https://doi.org/10.18632/aging.100523 pp 894—898

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Research Papers

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

Olga V. Leontieva, Geraldine M. Paszkiewicz, Mikhail V. Blagosklonny,

https://doi.org/10.18632/aging.100528 pp 899—916

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Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

Sudha Mannava, Kalyana C. Moparthy, Linda J. Wheeler, Katerina I. Leonova, Joseph A. Wawrzyniak, Anna Bianchi-Smiraglia, Albert E. Berman, Sheryl Flanagan, Donna S. Shewach, Nathalie C. Zeitouni, Andrei V. Gudkov, Christopher K. Mathews, Mikhail A. Nikiforov,

https://doi.org/10.18632/aging.100512 pp 917—922

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P73 and age-related diseases: is there any link with Parkinson Disease?

Francesca Grespi, Gerry Melino,

https://doi.org/10.18632/aging.100515 pp 923—931

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IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

Sona Hubackova, Katerina Krejcikova, Jiri Bartek, Zdenek Hodny,

https://doi.org/10.18632/aging.100520 pp 932—951

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Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

H. Dorota Halicka, Hong Zhao, Jiangwei Li, Yong-Syu Lee, Tze-Chen Hsieh, Joseph M. Wu, Zbigniew Darzynkiewicz,

https://doi.org/10.18632/aging.100521 pp 952—965

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Complete cardiac regeneration in a mouse model of myocardial infarction

Bernhard Johannes Haubner, Martyna Adamowicz-Brice, Sanjay Khadayate, Viktoria Tiefenthaler, Bernhard Metzler, Tim Aitman, Josef M. Penninger,

https://doi.org/10.18632/aging.100526 pp 966—977

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