Editorial Volume 4, Issue 12 pp 859—860

Figure 1. Adipose tissue mitochondria dysfunction protects against obesity and aging-related diseases. In TFAM KO adipose tissue, the combination of a decrease in Complex I activity with an increase of uncoupling state creates a mild mitochondria dysfunction without oxidative stress (Left). Upon high fat diet stress, adipose tissue mitochondria are overloaded, but adipose tissue mass remains small and insulin sensitive, despite signs of oxidative stress (Middle). Finally, severe mitochondria dysfunction is known to trigger high level of oxidative stress damage, impairs cellular function and promotes aged-related disorders such as insulin resistance (Right).