Research Paper Volume 4, Issue 12 pp 966—977

Complete cardiac regeneration in a mouse model of myocardial infarction


Figure 7. Differentially expressed genes between sham-operated and LAD-ligated mice left ventricles. (A) Venn diagram of differentially expressed genes in the left ventricle of non-manipulated, LAD-ligated and sham-operated mice, all from P10. The numbers of genes differentially expressed comparing non-manipulated P10 vs LAD-ligated hearts, non-manipulated P10 vs sham-operated heart, and LAD-ligated vs sham-operated hearts are indicated. (B) MA plots showing the distribution of gene expression plotted against log(fold change) for each gene in each pair-wise comparison of P10, LAD-ligated and sham-operated mice. Red dots indicate differentially expressed genes (Padj < 0.05), black dots indicate non-differentially expressed genes. (C) Reactome analysis of differentially expressed genes between sham-operated and LAD-ligated left ventricles at P10 revealing that the majority of these genes are annotated to the regulation of and mitosis cell cycle control as well as extracellular matrix and collagen pathways.