Research Paper Volume 6, Issue 3 pp 215—230

Figure 1. The summary of up- and down- regulated pathways based on GSEA during aging. (A) It showed the numbers of significantly identified pathways based on GSEA in each period during aging in C. elegans (red is for up-regulated and green is for down-regulated). Obviously, there were 42 up-regulated and 42 down-regulated significantly associated pathways from the stage of L4 to D6, as well as 26 up-regulated and 56 down-regulated significantly associated pathways from the stage of D6 to D15. (B) The Venn diagram showed the comparisons of each pathway group above. L4-D6 down represents the group of identified down-regulated pathways from the stage of L4 to D6; L4-D6 up represents the group of identified up-regulated pathways from the stage of L4 to D6; D6-D15 down represents the group of identified down-regulated pathways from the stage of D6 to D15; D6-D15 up represents the group of identified up-regulated pathways from the stage of D6 to D15. The boxes showed the mainly involved functional categories (KEGG Pathway Maps) as well as the percentage of each category.