Figure 2. TRIP13 over-expression human fibroblast cells are resistant to stressors of oxidation, apoptosis and DNA damage. (A) After 600uM H2O2 treatment, the TRIP13 over-expression fibroblast cells showed enhanced cell numbers when compared to control cells, wild type (WT) and empty vector (p<0.0001). (B) TRIP13 over-expression fibroblasts were treated with 10uM etoposide for 3 days, and exhibited higher cell numbers following treatment (p<0.001). (C) TRIP13 cells demonstrated significantly higher resistance after UV radiation when compared to the control groups (p<0.01). (Relative cell survival was as compared to numbers of cells plated originally, prior to culturing and stressors.) * indicates significant differences between groups.