Research Paper Volume 7, Issue 1 pp 1—13

PCH-2 regulates Caenorhabditis elegans lifespan


Figure 5. Inhibition of pch-2 by RNAi impacts lifespan of pch-2 over-expressing C. elegans. (A) A shortened lifespan, both median (30%) and maximum (56%), was induced by pch-2-specific RNAi in C. elegans that were engineered to over-express pch-2 (n=101), as compared to RNAi vector lines (n=60) (p <0.0001). (B) qRT-PCR validated the RNAi effect, indicating a significant reduction (~70%) of pch-2 transcripts in pch-2 over-expressing worms treated with RNAi. ***p <0.001.