Figure 7. Proposed interactions of pch-2 and sir-2 in aging in C. elegans. Based on our data and the literature, we propose that pch-2 may, similar to sir-2, affect the aging process of C. elegans. Briefly, pch-2 may play roles in surveillance of DNA damage and chromatin regulation, in concert with sir-2. Reduction of pch-2 expression induces genome instability and transcriptional dysregulation, and, therefore, may promote aging in C. elegans.