Editorial Volume 7, Issue 7 pp 467—468

β-catenin in epithelial tumorigenesis


Figure 1. The proposed models for the functions of β-catenin in epithelial differentiation and tumorigenesis of thymus and prostate. (A) β-catenin is critical for maintaining mTEC differentiation and preventing cTEC differentiation of bi-potent progenitors, whereas over-activated β-catenin drives thymoma initiation and progression. (B) β-catenin is required for basal-to-luminal differentiation and basal-derived prostate cancer progression. In contrast, β-catenin is dispensable for luminal-derived tumors.