Research Paper Volume 7, Issue 12 pp 1086—1093

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)


Figure 1. (A) After 4 weeks of 2′-O-methoxyethyl chimeric ASO treatment, mIndy mRNA expression was reduced by 91%. (B) Fasting plasma insulin concentrations were markedly reduced in the mIndy ASO treated rats. (C) Fasting glucose concentrations in the mIndy ASO and control ASO treated groups. All data are mean ± SEM, N=10 for each group; significances by double sided t-test.