Research Paper Volume 8, Issue 3 pp 427—439

Figure 4. Tg(Math1^E-Aβ42^Arc)1Lt/129 mice showed dramatic hearing impairment for high-frequency sound over time. (A) Representative ABR data (Red line) of non-Tg (B6/129) and Math1^E-Aβ42^Arc (Tg(Math1^E-Aβ42^Arc)1Lt/129) mice in age 2 month for the 32 kHz at 40 dB. There were at least three peaks (I–III) in both genotypes (see METHODS). (B) Representative ABR data (Red line) of non-Tg (B6/129) and Math1^E-Aβ42^Arc (Tg(Math1^E-Aβ42^Arc)1Lt/129) mice in age 4 month for the 32 kHz at 40 dB. No first peak was observed in Math1^E-Aβ42^Arc mice (arrow). (C) ABR threshold of non-Tg (B6/129) (white bar) and Math1^E-Aβ42^Arc (Tg(Math1^E-Aβ42^Arc)1Lt/129) (black bar) mice in age 2 and 4 months for the 32 kHz at 40dB. (D-G) ABR threshold of Tg(Math1^E-Aβ42^Arc)1Lt/129 and non-Tg (B6/129) mice from age 2 to 8 months for the 32 kHz tone (D), 16 kHz tone (E), and 8 kHz (F), and click sound (G). Tg(Math1^E-Aβ42^Arc)1Lt/129 mice (filled circles) showed increasing ABR threshold compared with non-Tg (open circles) (D). No increase in ABR threshold was observed for the 16 kHz tone (E), 8 kHz tone (F), or click sound (G). Data represent the mean ± SEM. non-Tg: n = 4 (3 male, 1 female); Tg: n = 4 (2 male, 2 female). **P < 0.01.