Review Volume 8, Issue 4 pp 603—619

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Figure 3. Bcl-2 protein subgroups. The Bcl-2 proteins are classified into three subgroups, one group with anti-apoptotic and two with pro-apoptotic function, depending on the composition of the typical BH domains, listed from BH1 to BH4. Representative members of each subfamily are shown.