Review Volume 8, Issue 4 pp 603—619

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Figure 4. Function of inhibitors of apoptosis proteins (IAPs). IAPs are often overexpressed in cancer and they have the ability to bind and inactivate caspases 9 and 3. The activities of IAPs, on the other hand, may be suppressed by mitochondrial proteins, such as Omi/HtrA2 and Smac/DIABLO, released into the cytosol during apoptosis.