In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

Alexander Aliper; Aleksey V. Belikov; Andrew Garazha; Leslie Jellen; Artem Artemov; Maria Suntsova; Alena Ivanova; Larisa Venkova; Nicolas Borisov; Anton Buzdin; Polina Mamoshina; Evgeny Putin; Andrew G. Swick; Alexey Moskalev; Alex Zhavoronkov

doi:doi:10.18632/aging.101047

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Research Paper Volume 8, Issue 9 pp 2127—2152

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

Figure 1. Flow cytometric characterization of fibroblasts upon incubation with the test substances. (A) Cell viability, (B) FSC (Forward-scattered light) - cell size metric, (C) SSC (Side-scattered light) - granularity metric, (D) FL1 - fluorescence metric. Group codes are listed in Table 1.