Volume 8, Issue 9

September 2016
pp 1830—2255

About the Cover

DNA methylation-based measures of biological age: meta-analysis predicting time to death, see Chen, et al .

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Table of Contents

Editorials

Bcl-xL inhibition - a novel strategy for glioma therapy

Georg Karpel-Massler, Markus D. Siegelin,

https://doi.org/10.18632/aging.101074 pp 1830—1831

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Addiction to RUNX in lymphoma

James C. Neil, Gillian Borland, Anna Kilbey,

https://doi.org/10.18632/aging.101071 pp 1832—1833

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BIM-mediated apoptosis and oncogene addiction

Yulin Li, Anja Deutzmann, Dean W. Felsher,

https://doi.org/10.18632/aging.101072 pp 1834—1835

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Fortifying p53 – beyond Mdm2 inhibitors

Anusha Sriraman, Yizhu Li, Matthias Dobbelstein,

https://doi.org/10.18632/aging.101073 pp 1836—1837

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Research Perspective

Targeting therapy for homocysteic acid in the blood represents a potential recovery treatment for cognition in Alzheimer’s disease patients

Tohru Hasegawa, Wataru Ukai,

https://doi.org/10.18632/aging.101046 pp 1838—1843

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Priority Research Paper

DNA methylation-based measures of biological age: meta-analysis predicting time to death

Brian H. Chen, Riccardo E. Marioni, Elena Colicino, Marjolein J. Peters, Cavin K. Ward-Caviness, Pei-Chien Tsai, Nicholas S. Roetker, Allan C. Just, Ellen W. Demerath, Weihua Guan, Jan Bressler, Myriam Fornage, Stephanie Studenski, Amy R. Vandiver, Ann Zenobia Moore, Toshiko Tanaka, Douglas P. Kiel, Liming Liang, Pantel Vokonas, Joel Schwartz, Kathryn L. Lunetta, Joanne M. Murabito, Stefania Bandinelli, Dena G. Hernandez, David Melzer, Michael Nalls, Luke C. Pilling, Timothy R. Price, Andrew B. Singleton, Christian Gieger, Rolf Holle, Anja Kretschmer, Florian Kronenberg, Sonja Kunze, Jakob Linseisen, Christine Meisinger, Wolfgang Rathmann, Melanie Waldenberger, Peter M. Visscher, Sonia Shah, Naomi R. Wray, Allan F. McRae, Oscar H. Franco, Albert Hofman, André G. Uitterlinden, Devin Absher, Themistocles Assimes, Morgan E. Levine, Ake T. Lu, Philip S. Tsao, Lifang Hou, JoAnn E. Manson, Cara L. Carty, Andrea Z. LaCroix, Alexander P. Reiner, Tim D. Spector, Andrew P. Feinberg, Daniel Levy, Andrea Baccarelli, Joyce van Meurs, Jordana T. Bell, Annette Peters, Ian J. Deary, James S. Pankow, Luigi Ferrucci, Steve Horvath,

https://doi.org/10.18632/aging.101020 pp 1844—1865

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Research Papers

Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice

Vladimir N. Anisimov, Irina G. Popovich, Mark A. Zabezhinski, Maria N. Yurova, Margarita L. Tyndyk, Ivan V. Anikin, Peter A. Egormin, Irina A. Baldueva, Elena I. Fedoros, Sergey E. Pigarev, Andrey V. Panchenko,

https://doi.org/10.18632/aging.101024 pp 1866—1875

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Crosstalk of clock gene expression and autophagy in aging

Faiza Kalfalah, Linda Janke, Alfonso Schiavi, Julia Tigges, Alexander Ix, Natascia Ventura, Fritz Boege, Hans Reinke,

https://doi.org/10.18632/aging.101018 pp 1876—1895

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Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study

Elisabetta Valentini, Michele Zampieri, Marco Malavolta, Maria Giulia Bacalini, Roberta Calabrese, Tiziana Guastafierro, Anna Reale, Claudio Franceschi, Antti Hervonen, Bernhard Koller, Jürgen Bernhardt, P. Eline Slagboom, Olivier Toussaint, Ewa Sikora, Efstathios S. Gonos, Nicolle Breusing, Tilman Grune, Eugène Jansen, Martijn E.T. Dollé, María Moreno-Villanueva, Thilo Sindlinger, Alexander Bürkle, Fabio Ciccarone, Paola Caiafa,

https://doi.org/10.18632/aging.101022 pp 1896—1922

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Disruption of mechanical stress in extracellular matrix is related to Stanford type A aortic dissection through down-regulation of Yes-associated protein

Wen-Jian Jiang, Wei-Hong Ren, Xu-Jie Liu, Yan Liu, Fu-Jian Wu, Li-Zhong Sun, Feng Lan, Jie Du, Hong-Jia Zhang,

https://doi.org/10.18632/aging.101033 pp 1923—1939

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Higher expression of somatic repair genes in long-lived ant queens than workers

Eric R. Lucas, Eyal Privman, Laurent Keller,

https://doi.org/10.18632/aging.101027 pp 1940—1951

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PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration

Mayur Choudhary, Jin-dong Ding, Xiaoping Qi, Michael E. Boulton, Pei-Li Yao, Jeffrey M. Peters, Goldis Malek,

https://doi.org/10.18632/aging.101031 pp 1952—1978

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An intestinal microRNA modulates the homeostatic adaptation to chronic oxidative stress in C. elegans

Masaomi Kato, Mohammed Abul Kashem, Chao Cheng,

https://doi.org/10.18632/aging.101029 pp 1979—2005

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SATB2-Nanog axis links age-related intrinsic changes of mesenchymal stem cells from craniofacial bone

Peipei Zhou, Geng Wu, Ping Zhang, Rongyao Xu, Jie Ge, Yu Fu, Yuchao Zhang, Yifei Du, Jinhai Ye, Jie Cheng, Hongbing Jiang,

https://doi.org/10.18632/aging.101041 pp 2006—2022

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Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer

Hu Zhou, Fubing Wang, Hao Chen, Qian Tan, Shili Qiu, Shanshan Chen, Wei Jing, Mingxia Yu, Chunzi Liang, Shengwei Ye, Jiancheng Tu,

https://doi.org/10.18632/aging.101048 pp 2023—2038

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Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936

Thalia S. Field, Fergus N. Doubal, Wendy Johnson, Ellen Backhouse, Caroline McHutchison, Simon Cox, Janie Corley, Alison Pattie, Alan J. Gow, Susan Shenkin, Vera Cvoro, Zoe Morris, Julie Staals, Mark Bastin, Ian J. Deary, Joanna M. Wardlaw,

https://doi.org/10.18632/aging.101043 pp 2039—2061

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Age-associated repression of type 1 inositol 1, 4, 5-triphosphate receptor impairs muscle regeneration

Jeong Yi Choi, Chae Young Hwang, Bora Lee, Seung-Min Lee, Young Jae Bahn, Kwang-Pyo Lee, Moonkyung Kang, Yeon-Soo Kim, Sun-Hee Woo, Jae-Young Lim, Eunhee Kim, Ki-Sun Kwon,

https://doi.org/10.18632/aging.101039 pp 2062—2080

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Age-related hearing loss: prevention of threshold declines, cell loss and apoptosis in spiral ganglion neurons

Robert D. Frisina, Bo Ding, Xiaoxia Zhu, Joseph P. Walton,

https://doi.org/10.18632/aging.101045 pp 2081—2099

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Cell cycle controls stress response and longevity in C. elegans

Matthias Dottermusch, Theresa Lakner, Tobias Peyman, Marinella Klein, Gerd Walz, Elke Neumann-Haefelin,

https://doi.org/10.18632/aging.101052 pp 2100—2126

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In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

Alexander Aliper, Aleksey V. Belikov, Andrew Garazha, Leslie Jellen, Artem Artemov, Maria Suntsova, Alena Ivanova, Larisa Venkova, Nicolas Borisov, Anton Buzdin, Polina Mamoshina, Evgeny Putin, Andrew G. Swick, Alexey Moskalev, Alex Zhavoronkov,

https://doi.org/10.18632/aging.101047 pp 2127—2152

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Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits

Stephen J. Bonasera, Jyothi Arikkath, Michael D. Boska, Tammy R. Chaudoin, Nicholas W. DeKorver, Evan H. Goulding, Traci A. Hoke, Vahid Mojtahedzedah, Crystal D. Reyelts, Balasrinivasa Sajja, A. Katrin Schenk, Laurence H. Tecott, Tiffany A. Volden,

https://doi.org/10.18632/aging.101040 pp 2153—2181

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LncRNA mediated regulation of aging pathways in Drosophila melanogaster during dietary restriction

Deying Yang, Ting Lian, Jianbo Tu, Uma Gaur, Xueping Mao, Xiaolan Fan, Diyan Li, Ying Li, Mingyao Yang,

https://doi.org/10.18632/aging.101062 pp 2182—2203

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Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma

Jun Chi, Qing Yang, Xiao-Feng Xie, Xian-Zi Yang, Mei-Yin Zhang, Hui-Yun Wang, Guo-Liang Xu,

https://doi.org/10.18632/aging.101037 pp 2204—2221

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Specific premature epigenetic aging of cartilage in osteoarthritis

Laura Vidal-Bralo, Yolanda Lopez-Golan, Antonio Mera-Varela, Ignacio Rego-Perez, Steve Horvath, Yuhua Zhang, Álvaro del Real, Guangju Zhai, Francisco J. Blanco, Jose A. Riancho, Juan J. Gomez-Reino, Antonio Gonzalez,

https://doi.org/10.18632/aging.101053 pp 2222—2231

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Global gene profiling of aging lungs in Atp8b1 mutant mice

Ramani Soundararajan, Timothy M. Stearns, Alexander Czachor, Jutaro Fukumoto, Christina Turn, Emma Westermann-Clark, Mason Breitzig, Lee Tan, Richard F. Lockey, Benjamin L. King, Narasaiah Kolliputi,

https://doi.org/10.18632/aging.101056 pp 2232—2252

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Letter to the Editor

Deep biomarkers of aging are population-dependent

Alan A. Cohen, Vincent Morissette-Thomas, Luigi Ferrucci, Linda P. Fried,

https://doi.org/10.18632/aging.101034 pp 2253—2255

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