Research Paper Volume 8, Issue 11 pp 2747—2753

Figure 2. On-target effects of PI3Kα inhibition in ob/ob mice. (A) Glucose serum excursions after a single administration of vehicle, BYL-719 (5 or 10 mg/kg), GS-9820 (5 or 10 mg/kg) or CNIO-PI3Ki (1 or 5 mg/kg) by oral gavage (n=10 per group, ob/ob males, 20 weeks old). Treatments and measurements were done under ad libitum feeding. (B) Glucose serum excursions measured 7 days after the beginning of the treatment in the same mice as in Figure 2A. (C) Relative food and water intake in the same mice as in Figure 1A. The results correspond to the average daily food and water intake from days 7 to 12. Values correspond to average ± s.d. Statistical significance was determined by the two-tailed Student’s t-test relative to vehicle controls: * p < 0.05, ** p <0.01, *** p <0.001. In Figures 2A and 2B, significant differences were found from 0.5 h to 6 h post-gavage, except for acalisib that is significant only at 1 h, indicated with # (1h).