Volume 8, Issue 11

November 2016
pp 2605—3150

About the Cover

The cover for issue 11 of Aging features Figure 6B, ''Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction" from Halade et al.

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Table of Contents

Editorials

Developing cancer therapies – think global

Andrew D. Hollenbach,

https://doi.org/10.18632/aging.101129 pp 2605—2606

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Cancer immunotherapy: weak beats strong

Wolfgang Deppert, Michael Bruns,

https://doi.org/10.18632/aging.101134 pp 2607—2608

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Biocomputing drug repurposing toward targeted therapies

Luca Cardone,

https://doi.org/10.18632/aging.101135 pp 2609—2610

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Research Papers

Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction

Ganesh V. Halade, Vasundhara Kain, Laurence M. Black, Sumanth D. Prabhu, Kevin A. Ingle,

https://doi.org/10.18632/aging.101077 pp 2611—2634

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Distinct patterns of simple sequence repeats and GC distribution in intragenic and intergenic regions of primate genomes

Wen-Hua Qi, Chao-chao Yan, Wu-Jiao Li, Xue-Mei Jiang, Guang-Zhou Li, Xiu-Yue Zhang, Ting-Zhang Hu, Jing Li, Bi-Song Yue,

https://doi.org/10.18632/aging.101025 pp 2635—2654

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Ischemic stroke patients are biologically older than their chronological age

Carolina Soriano-Tárraga, Eva Giralt-Steinhauer, Marina Mola-Caminal, Rosa M. Vivanco-Hidalgo, Angel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Sergi Sayols-Baixeras, Roberto Elosua, Jaume Roquer, Jordi Jiménez-Conde,

https://doi.org/10.18632/aging.101028 pp 2655—2666

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The progeroid gene BubR1 regulates axon myelination and motor function

Chan-Il Choi, Ki Hyun Yoo, Syed Mohammed Qasim Hussaini, Byeong Tak Jeon, John Welby, Haiyun Gan, Isobel A. Scarisbrick, Zhiguo Zhang, Darren J. Baker, Jan M. van Deursen, Moses Rodriguez, Mi-Hyeon Jang,

https://doi.org/10.18632/aging.101032 pp 2667—2688

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Investigating the associations between adiposity, life course overweight trajectories, and telomere length

Wahyu Wulaningsih, Johnathan Watkins, Tetsuya Matsuguchi, Rebecca Hardy,

https://doi.org/10.18632/aging.101036 pp 2689—2701

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Mutational load of the mitochondrial genome predicts pathological features and biochemical recurrence in prostate cancer

Anton M.F. Kalsbeek, Eva F.K. Chan, Judith Grogan, Desiree C. Petersen, Weerachai Jaratlerdsiri, Ruta Gupta, Ruth J. Lyons, Anne-Maree Haynes, Lisa G. Horvath, James G. Kench, Phillip D. Stricker, Vanessa M. Hayes,

https://doi.org/10.18632/aging.101044 pp 2702—2712

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An antioxidant specifically targeting mitochondria delays progression of Alzheimer’s disease-like pathology

Natalia A. Stefanova, Natalia A. Muraleva, Kseniya Yi. Maksimova, Ekaterina A. Rudnitskaya, Elena Kiseleva, Darya V. Telegina, Nataliya G. Kolosova,

https://doi.org/10.18632/aging.101054 pp 2713—2733

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Characterization of variations in IL23A and IL23R genes: possible roles in multiple sclerosis and other neuroinflammatory demyelinating diseases

Fei-Feng Li, Xi-Dong Zhu, Peng Yan, Mei-Hua Jin, Hui Yue, Qiong Zhang, Jin Fu, Shu-Lin Liu,

https://doi.org/10.18632/aging.101058 pp 2734—2746

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PI3Kα inhibition reduces obesity in mice

Elena Lopez-Guadamillas, Maribel Muñoz-Martin, Sonia Martinez, Joaquin Pastor, Pablo J. Fernandez-Marcos, Manuel Serrano,

https://doi.org/10.18632/aging.101075 pp 2747—2753

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Aging is associated with an expansion of CD49f^hi mammary stem cells that show a decline in function and increased transformation potential

Qiaoxiang Dong, Hui Gao, Yuanshuo Shi, Fuchuang Zhang, Xiang Gu, Anqi Wu, Danhan Wang, Yuanhong Chen, Abhik Bandyopadhyay, I-Tien Yeh, Benjamin J. Daniel, Yidong Chen, Yi Zou, Vivienne L. Rebel, Christi A. Walter, Jianxin Lu, Changjiang Huang, Lu-Zhe Sun,

https://doi.org/10.18632/aging.101082 pp 2754—2776

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Long-term caloric restriction in ApoE-deficient mice results in neuroprotection via Fgf21-induced AMPK/mTOR pathway

Claire Rühlmann, Tjark Wölk, Tobias Blümel, Laura Stahn, Brigitte Vollmar, Angela Kuhla,

https://doi.org/10.18632/aging.101086 pp 2777—2789

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Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage

Xinxin Wang, Feng Liu, Xiaoyu Qin, Tinglei Huang, Bo Huang, Yanjie Zhang, Bin Jiang,

https://doi.org/10.18632/aging.101087 pp 2790—2798

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Expansion induced microRNA changes in bone marrow mesenchymal stromal cells reveals interplay between immune regulation and cell cycle

Lotta Kilpinen, Amarjit Parmar, Dario Greco, Matti Korhonen, Petri Lehenkari, Päivi Saavalainen, Saara Laitinen,

https://doi.org/10.18632/aging.101088 pp 2799—2813

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Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions

Ishita Parikh, Janet Guo, Kai-Hsiang Chuang, Yu Zhong, Ralf G. Rempe, Jared D. Hoffman, Rachel Armstrong, Björn Bauer, Anika M.S. Hartz, Ai-Ling Lin,

https://doi.org/10.18632/aging.101094 pp 2814—2826

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Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast

Jun Liu, Ming-Hong He, Jing Peng, Yi-Min Duan, Yi-Si Lu, Zhenfang Wu, Ting Gong, Hong-Tao Li, Jin-Qiu Zhou,

https://doi.org/10.18632/aging.101095 pp 2827—2847

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No effect of testosterone on behavior in aged Wistar rats

Veronika Borbélyová, Emese Domonkos, Janka Bábíčková, Ľubomíra Tóthová, Martin Bosý, Július Hodosy, Peter Celec,

https://doi.org/10.18632/aging.101096 pp 2848—2861

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Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naïve patients

Chenghao Su, Yong Lin, Qianguo Mao, Daitze Wu, Lina Zhu, Isabel Najera, Fernando Garcia-Alcalde, Jianjun Niu,

https://doi.org/10.18632/aging.101097 pp 2862—2870

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Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function

Juhyun Oh, Indranil Sinha, Kah Yong Tan, Bernard Rosner, Jonathan M. Dreyfuss, Ornela Gjata, Peter Tran, Steven E. Shoelson, Amy J. Wagers,

https://doi.org/10.18632/aging.101098 pp 2871—2896

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Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice

Rachel A. Gioscia-Ryan, Micah L. Battson, Lauren M. Cuevas, Melanie C. Zigler, Amy L. Sindler, Douglas R. Seals,

https://doi.org/10.18632/aging.101099 pp 2897—2914

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Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

Yingying Wang, Jianhui Chang, Xingui Liu, Xuan Zhang, Suping Zhang, Xin Zhang, Daohong Zhou, Guangrong Zheng,

https://doi.org/10.18632/aging.101100 pp 2915—2926

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Regulation of human cerebrospinal fluid malate dehydrogenase 1 in sporadic Creutzfeldt-Jakob disease patients

Matthias Schmitz, Franc Llorens, Alexander Pracht, Tobias Thom, Ângela Correia, Saima Zafar, Isidre Ferrer, Inga Zerr,

https://doi.org/10.18632/aging.101101 pp 2927—2935

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Molecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells

Ivan Petrov, Maria Suntsova, Olga Mutorova, Maxim Sorokin, Andrew Garazha, Elena Ilnitskaya, Pavel Spirin, Sergey Larin, Olga Kovalchuk, Vladimir Prassolov, Alex Zhavoronkov, Alexander Roumiantsev, Anton Buzdin,

https://doi.org/10.18632/aging.101102 pp 2936—2947

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Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p

Peng Song, Shu-Cheng Yin,

https://doi.org/10.18632/aging.101103 pp 2948—2960

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Depressive symptoms are associated with leukocyte telomere length in American Indians: findings from the Strong Heart Family Study

Qi Zhao, Yun Zhu, Fawn Yeh, Jue Lin, Elisa T. Lee, Shelley A. Cole, Darren Calhoun, Jinying Zhao,

https://doi.org/10.18632/aging.101104 pp 2961—2970

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A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA)

Thalyana Smith-Vikos, Zuyun Liu, Christine Parsons, Myriam Gorospe, Luigi Ferrucci, Thomas M. Gill, Frank J. Slack,

https://doi.org/10.18632/aging.101106 pp 2971—2987

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Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila

Brian Xia, Ed Gerstin, Dustin E. Schones, Wendong Huang, J. Steven de Belle,

https://doi.org/10.18632/aging.101107 pp 2988—3008

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Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response

Hongrui Guo, Hengmin Cui, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zhao, Kejie Chen, Jie Deng,

https://doi.org/10.18632/aging.101108 pp 3009—3027

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Rpd3 interacts with insulin signaling in Drosophila longevity extension

Jared K. Woods, Tahereh Ziafazeli, Blanka Rogina,

https://doi.org/10.18632/aging.101110 pp 3028—3044

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On the heterogeneity of human populations as reflected by mortality dynamics

Demetris Avraam, Séverine Arnold, Olga Vasieva, Bakhtier Vasiev,

https://doi.org/10.18632/aging.101112 pp 3045—3064

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Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation

Irina Tsoy Nizamutdinova, Giuseppina F. Dusio, Olga Yu. Gasheva, Hunter Skoog, Richard Tobin, Chander Peddaboina, Cynthia J. Meininger, David C. Zawieja, M. Karen Newell-Rogers, Anatoliy A. Gashev,

https://doi.org/10.18632/aging.101113 pp 3065—3090

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The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Jutaro Fukumoto, Ramani Soundararajan, Joseph Leung, Ruan Cox Jr., Sanjay Mahendrasah, Neha Muthavarapu, Travis Herrin, Alexander Czachor, Lee C. Tan, Nima Hosseinian, Priyanshi Patel, Jayanthraj Gone, Mason T. Breitzig, Young Cho, Andrew J. Cooke, Lakshmi Galam, Venkata Ramireddy Narala, Yashwant Pathak, Richard F. Lockey, Narasaiah Kolliputi,

https://doi.org/10.18632/aging.101115 pp 3091—3109

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Immune function parameters as markers of biological age and predictors of longevity

Irene Martínez de Toda, Ianire Maté, Carmen Vida, Julia Cruces, Mónica De la Fuente,

https://doi.org/10.18632/aging.101116 pp 3110—3119

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Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

Peter C. Reifsnyder, Kevin Flurkey, Austen Te, David E. Harrison,

https://doi.org/10.18632/aging.101117 pp 3120—3130

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Early age decline in DNA repair capacity in the liver: in depth profile of differential gene expression

Avital Guedj, Anat Geiger-Maor, Hadar Benyamini, Yaval Nevo, Sharona Elgavish, Eithan Galun, Hagai Amsalem, Jacob Rachmilewitz,

https://doi.org/10.18632/aging.101120 pp 3131—3146

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Letter to the Editor

The Fhit protein: an opportunity to overcome chemoresistance

Eugenio Gaudio, Francesco Paduano, Carlo M. Croce, Francesco Trapasso,

https://doi.org/10.18632/aging.101123 pp 3147—3150

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