Research Paper Volume 8, Issue 11 pp 2611—2634

Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction

Figure 1. Excess fatty acid influx depleted LOXs in young and aging post-MI. (A) Study design indicating young (6 months) and aging (18 months) mice on an omega-6 fatty acids enriched safflower oil diet protocol. (B) No-MI naïve control and infarcted LV stained with periodic acid-Schiff (PAS) at d1 post-MI in young and aging, with and without fatty acid enriched diet. No-MI control represents the steady state naïve control mice (C) mRNA expression of LOXs (5,12,15) and TNF-α in infarcted LV. *p<0.05 vs young-LC; $ p<0.05 LC vs SO. Values are means ±SEM; n=2-4/group.