HIF-1–dependent regulation of lifespan in <i>Caenorhabditis elegans</i> by the acyl-CoA–binding protein MAA-1

Mehrnaz Shamalnasab; Manel Dhaoui; Manjunatha Thondamal; Eva Bang Harvald; Nils J. Færgeman; Hugo Aguilaniu; Paola Fabrizio

doi:doi:10.18632/aging.101267

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Research Paper Volume 9, Issue 7 pp 1745—1769

HIF-1–dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA–binding protein MAA-1

Figure 1. ACBPs regulate C. elegans lifespan. (A) Downregulation of maa-1 promotes longevity. Lifespans of wildtype worms (N2) subjected to control RNAi vs maa-1 dsRNA, P<0.0001. (B) Downregulation of acbp-1 or acbp-3 modestly increases longevity. Lifespans of wild-type worms subjected to control RNAi vs acbp-1 RNAi, P<0.01; and control RNAi vs acbp-3 RNAi, P=0.056. (C-D) Loss-of-function mutations maa-1(ok2033) (C) and maa-1(sv38) (D) prolong lifespan (both P<0.0001). P values were calculated using the log-rank (Mantel-Cox) method. Replicate experiments and details of statistical analyses are shown in Table S1 and S2.