Research Paper Volume 9, Issue 7 pp 1745—1769

HIF-1–dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA–binding protein MAA-1

Figure 2. Loss of maa-1 promotes heat, oxidative, and proteotoxic stress resistance. (A-B) maa-1(ok2033) mutants showed enhanced resistance to incubation at 35°C (A) and exposure to 150 mM paraquat (B). Error bars represent SEM from three independent experiments (*P˂0.05, **P˂0.01 compared to wildtype worms by Student’s t-test). (C-D) maa-1 RNAi increases resistance to paralysis induced by aggregation of a 35-residue polyglutamine repeat (C; P<0.0001) or human β-amyloid (D; P<0.0001). P values were calculated using the log-rank (Mantel-Cox) method. Replicate experiment is shown in Figure S2.