Research Paper Volume 9, Issue 7 pp 1745—1769

HIF-1–dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA–binding protein MAA-1

Figure 5. DAF-16 is required for lifespan extension in maa-1–deficient animals. Lifespan of maa-1(ok2033); daf-16(mu86) double mutants is significantly shorter than that of maa-1(ok2033) single mutants (P<0.0001). P values were calculated using the log-rank (Mantel-Cox) method. Replicate experiments and additional statistical analysis are shown in Table S1 and S2.