Research Paper Volume 9, Issue 11 pp 2245—2268

Towards natural mimetics of metformin and rapamycin

Figure 1. Workflow diagram showing multi-level analysis for screening and ranking nutraceuticals that mimic metformin and rapamycin in transcriptional and pathway activation response. A subset of 871 LINCS compounds were selected from the UNPD and KEGG BRITE databases. Perturbations with those compounds in cancer cell lines were compared with perturbations with metformin and rapamycin to estimate similarity at the gene and pathway level and deep learning techniques were employed to recognize the transcriptional signature of metformin and rapamycin and screen for matches amongst the LINCS compounds