Research Paper Volume 9, Issue 11 pp 2245—2268

Towards natural mimetics of metformin and rapamycin

Figure 2. DL-based similarity to metformin (A) and rapamycin (B). Significance of natural compound was determined as the -log10(p-value) and odds ratio for compound according to Fisher's exact test performed on the DNN output for each perturbed sample. Only compounds with -log10(p-value)>4 and odds ratio > 1 are shown.