Figure 3. Gene- and pathway-level similarity to metformin (A) and rapamycin (B). Significance of natural compound was determined as the -log10(p-value) of the most significant perturbation of compound according to Fisher's exact test. Percentage of common pathways designates the amount of pathways that have the same direction of the change as Metformin. Only compounds with -log10(p-value)>4 and over 50% of common pathways are shown.