Research Paper Volume 10, Issue 2 pp 229—240
Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)
Figure 13. TPP-related compounds provide a novel chemical strategy for targeting “bulk” cancer cells and CSCs, while minimizing off-target side-effects in normal cells. Our results suggest that “malignant” mitochondria are functionally distinct from “normal” mitochondria. See text for further details.