Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

Bela Ozsvari; Federica Sotgia; Michael P. Lisanti

doi:doi:10.18632/aging.101384

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Research Paper Volume 10, Issue 2 pp 229—240

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

Figure 14. bis-TPP: Structural activity relationships (SARs). Comparison of 2-butene-1,4-bis-TPP (see Figures 1 and 2) with p-xylylene-bis-TPP (see Figure 1 and Table 1), the latter of which is approximately 200-fold less potent, in the context of ATP depletion.