Research Paper Volume 10, Issue 2 pp 229—240

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

Figure 6. Impaired mitochondrial function of MCF-7 cells after treatment with various TPP derivatives: Compound 1. Oxygen consumption rate (OCR) was measured with a Seahorse XF96 Extracellular Flux Analyzer. Data are represented as mean +/- SEM. Note that 2-butene-1,4-bis-TPP effectively inhibits mitochondrial oxygen consumption. **p < 0.01; ***p < 0.001; indicates significance, all relative to the control.