Research Paper Volume 10, Issue 2 pp 229—240

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

Figure 8. Impaired mitochondrial function of MCF-7 cells after treatment with various TPP derivatives: Compounds 4 and 5. Oxygen consumption rate (OCR) was measured with a Seahorse XF96 Extracellular Flux Analyzer. Data are represented as mean +/- SEM. Note that 2,4-dichlorobenzyl-TPP and 1-naphtylmethyl-TPP both effectively inhibit mitochondrial oxygen consumption. **p < 0.01; ***p < 0.001; indicates significance, all relative to the control.