Research Paper Volume 10, Issue 4 pp 592—605

Mining TCGA database for genes of prognostic value in glioblastoma microenvironment

Figure 2. Comparison of gene expression profile with immune scores and stromal scores in GBM. Heatmaps were drawn based on the average linkage method and Pearson distance measurement method. Genes with higher expression are shown in red, lower expression are shown in green, genes with same expression level are in black. (A) Heatmap of the DEGs of immune scores of top half (high score) vs. bottom half (low score). p<0.05, fold change >1.5). (B) Heatmap of the DEGs of stromal scores of top half (high score) vs. bottom half (low score). p<0.05, fold change >1.5). (C, D) Venn diagrams showing the number of commonly upregulated (C) or downregulated (D) DEGs in stromal and immune score groups. (E, F, G) Top 10 GO terms. False discovery rate (FDR) of GO analysis was acquired from DAVID functional annotation tool. p <0.05.