Figure 2. Differentially expressed genes (DEGs) and enriched Gene Ontology (GO) terms in aged female vs. young female. (A) Comparisons include age and females only. (B) Volcano plot showing upregulated (mustard) and down-regulated (blue) DEGs with a minimum 1.5-fold change and a FDR <0.1. Text boxes highlight individual genes discussed in results section. (C) Gene ontology terms significantly enriched in the genes found to be significantly upregulated in aged female vs. young female mice. Many of these GO terms are related to endothelial cell signaling and maintenance. (D) GO terms of down-regulated genes in aged females.