Research Paper Volume 10, Issue 4 pp 606—621

Sex differences in transcriptomic profiles in aged kidney cells of renin lineage

Figure 4. Female and male aging gene dynamics are different. (A) Female-centric perspective. Expression pattern of aged female vs. young female DEGs (n=159) across all age and sex conditions. Group A genes (comprises 59.4% of all DEGs) are significantly up-regulated in aged vs. young female, but do not have any significant change in aged vs. young male. Group B genes decreased in both aged vs. young female and aged vs. young male. Group C genes show the opposite trend, as they are down-regulated in aged vs. young female, but up-regulated in aged vs. young male. (B) Male-centric perspective. Expression pattern of aged male vs. young male DEGs (n=503) across all age and sex conditions. Group A genes (comprises 9.7% of all DEGs) are up-regulated in aged vs. young male and are also moderately up-regulated in aged vs. young female. Group B genes are significantly down-regulated in aged vs. young male are up-regulated in aged female mice.