Figure 1. Shared and distinct gene expression profile among four tissues in KOAL mice. (a) Venn diagram of similar expressed genes across liver, skeletal muscle, brain and WAT tissue in KOAL mice. Significantly up-regulated genes are shown in red and significantly down-regulated genes are shown in blue. Common genes that are significantly up- or down-regulated are found in overlapping ovals. The numbers in the bottom far right denotes the number of genes expressed but not significantly up-regulated (red) or down-regulated (blue). (b) Up-regulated gene ontology (GO) terms in liver, skeletal muscle, brain and WAT of KOAL mice versus WTAL mice. (c) Down-regulated GO terms in liver, skeletal muscle, brain and WAT of KOAL mice.