Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice

Melissa M. Page; Eugene F. Schuster; Manikhandan Mudaliar; Pawel Herzyk; Dominic J. Withers; Colin Selman

doi:doi:10.18632/aging.101446

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Research Paper Volume 10, Issue 5 pp 1027—1052

Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice

Figure 3. Heat map of significantly differentially expressed genes in liver, skeletal muscle, brain and WAT from either KO^AL or WT^DR mice compared to WT^AL. A total of 1172 genes were significantly differentially expressed. Red represents up-regulated genes and blue represents down-regulated genes.