Research Paper Volume 10, Issue 6 pp 1223—1238

Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine

Figure 4. T4 administration restores thyroxine binding globulin gene expression and a subset of thyroid hormone responsive genes in the liver of Atrx Foxg1cre (cKO) mice at P14. (a) Serpina7 (thyroxine binding globulin) gene expression is restored following T4 treatment. (b) Administration of T4 restores thyroid hormone responsive gene expression of Dio1 and Thrβ in Atrx Foxg1cre mice to that of control mice. In addition, there is a dramatic repression of Dio3 expression in the liver of Atrx Foxg1cre mice at P14. (c) Despite normal expression of Thrβ, some thyroid hormone responsive genes are not rescued following T4 treatment in Atrx Foxg1cre mice. qRT-PCR data were normalized to β-actin expression, n=3-6. Groups with the same letter have means that are not significantly different. Groups with different letters have means that are significantly different (p<0.05). Error bars represent SEM.