Research Paper Volume 10, Issue 6 pp 1281—1293

CircSNCA downregulation by pramipexole treatment mediates cell apoptosis and autophagy in Parkinson’s disease by targeting miR-7

Figure 6. CircSNCA influenced the expression of autophagy-related proteins. (A) The expression of autophagy-related protein, LC3B-II, detected by western blot decreased in the circSNCA overexpression group, and increased in the circSNCA knockdown group, while that of LC3B-I showed little difference. *P < 0.05 compared with NC group, #P < 0.05 compared with circSNCA-OE. (B) PPX mediated apoptosis and autophagy of MPP+ treated SH-SY5Y cells by regulating circSNCA, which targeted miR-7.