Research Paper Volume 10, Issue 7 pp 1597—1608

Aging exacerbates mortality of Acinetobacter baumannii pneumonia and reduces the efficacies of antibiotics and vaccine

Figure 5. Increased chemokines mRNA expression after A.baumannii infection in aged mice. Young and aged mice were infected intratracheally with 5×106 CFU of LAC-4. At 0 h and 24 hpi, mRNA in lungs was isolated. CXCL1, CCL2, CCL7, CXCL2, and CXCL5 were measured by real-time PCR. Data are presented as mean ± SEM of four or five mice per condition and represent one of 2 independent experiments. Statistical analyses were performed by Student’s t test. *, P < 0.05, **, P < 0.01.